Journal: bioRxiv
Article Title: Epidermal growth factor (EGF) receptor family signalling in cardiomyocyte hypertrophy and heart failure
doi: 10.64898/2026.05.16.724529
Figure Lengend Snippet: A , Schematic of the EGFR family and the ligands that bind to them (left). Illustration of receptor homodimerization and heterodimerization that allows all EGFR family members to activate intracellular signalling, responding to, for example, EGF or NRG1 (right). Overexpression of receptors can also result in oligomerization and activation in the absence of ligand. B , mRNA expression of receptors (upper panel) and ligands (centre and lower panels) in each of 17 cell types (c-0 to c-17) identified in human heart tissue. Expression of the EGFR family (EGFR, ERBB2, ERBB3, ERBB4) is compared with the two receptors for endothelin-1 (EDNRA, EDNRB). Expression of EGFR family ligands (EGF, AREG, EREG, HBEGF, NRG1) is compared with expression of endothelin-1 (EDN1), an established agonist involved in cardiac hypertrophy . Data are from the Human Protein Atlas version 25.0. C-D , mRNA expression of endothelin and the EGFR family ( C ) and EGFR family ligands ( D ) in human failing hearts (HF) compared with non-failing hearts (NF). Statistical analysis used Mann-Whitney tests. p values for significant (p<0.05) changes are shown in bold type with values of 0.05-0.1 in standard type.
Article Snippet: Single cell mRNA data for heart tissue were collected from the Human Protein Atlas (HPA) version 25.0 (release date: 11 November 2025) [ ].
Techniques: Over Expression, Activation Assay, Expressing, MANN-WHITNEY